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In an interview with conservative radio talk show host and filmmaker John Ziegler, Palin questioned whether Kennedy was getting better treatment than Palin did as Republican presidential candidate John McCain's running mate. Clips from Ziegler's interview were posted on YouTube this week.

"I've been interested to see how Caroline Kennedy will be handled and if she will be handled with kid gloves or if she will be under such a microscope," Palin said.

Some of the critics see the issue as a liberal or Democratic bias. Others see background _ Palin from Alaska and Kennedy from Manhattan _ as the reason for what they consider different treatment of the women.

Palin herself suggested class issues could be behind the differences in coverage, saying ". we will perhaps be able to prove that there is a class issue here also that was such a factor in the scrutiny of my candidacy versus, say, the scrutiny of what her candidacy may be."

"There is clearly an urban centric, or urban elitism, attitude that pervades much of the media as we know it on many issues," said Nancy Larraine Hoffman, a former journalism instructor and New York state senator.

"You have the combined effect here of a stereotypical expectation of successful women, going to Wellesley, holding law degrees like Hillary Clinton," she said. "Caroline Kennedy perhaps is more in tune with many of the people in the media rather than someone who can quickly be cast in a whole other light because she happens to live in a rural area."

The difference in treatment ugg uk could also be explained by the position each woman had been seeking. Palin was hoping to become the nation's first female vice president, just second in command to 72 year old Sen. John McCain. Meanwhile, Kennedy is vying to be named one of 100 Senators.

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New York news media also uggs christmas have published or broadcast numerous stories containing criticism of Kennedy's lack of experience in elective office and whether she is the best choice to replace Sen. Hillary Rodham Clinton, who has been asked to join the Obama administration as secretary of state. senator, but rather on the seemingly arbitrary ways in which news organizations determine the level and kind of scrutiny given to those who aspire to public office. In fact, I consider Ms. Kennedy qualified and experienced, and she could serve New York well."

In the interview, Palin criticized the news media's coverage of her and her family, telling Ziegler that CBS News anchor Katie Couric and comic actress Tina Fey had been "exploiting" her. Palin gave Couric a rare interview at the beginning of her campaign for vice president, and Fey frequently impersonated Palin on "Saturday Night Live."

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sees chance for global ban on cluster bombs

UNITED NATIONS (Reuters) The United Nations sees renewed momentum for a global ban on cluster bombs as more than 100 nations but not the world's top users and stockpilers gather in Dublin to finalize an anti cluster munitions treaty. official and diplomats from countries that support a ban say there is a good chance that the conference, which starts on Monday and runs through May 30, will end with the signing of a treaty outlawing cluster bombs. Development Program, told Reuters.

There is an increasing "awareness that leaving so many devices spread around is taking away the peace from people after conflicts, particularly for children," he said.

Cluster munitions canada goose boxing day open in mid air and scatter as many as several hundred "bomblets" over wide areas. They often fail to explode, creating virtual mine fields that can kill or injure anyone who comes across them.

The UNDP says cluster munitions have caused more than 13,000 confirmed canada goose outlet injuries and deaths around the world, the vast majority of them in Laos, Vietnam, Afghanistan, Iraq and Lebanon.

The so called Oslo process against the bombs began three years ago and is modelled on the campaign against anti personnel land mines, which won the Nobel Peace Prize in 1997 and led to the 1999 Ottawa Treaty banning them. Secretary General Ban Ki moon was playing a key role in the Norwegian led campaign against cluster bombs by actively advocating a ban. OPPOSES BAN ON CLUSTER BOMBS

The top producers, users and stockpilers of cluster bombs the United States, Israel, China, Russia, India and Pakistan will skip the conference. But diplomats say Washington is encouraging allies to adopt positions that could lead to a watered down treaty. and a handful of other states continue to insist on their need to use a weapon that the rest of world is banning," said Steve Goose, director of the arms division at the New York based Human Rights Watch.

"But we believe that a strong new treaty will stigmatize cluster munitions to such a degree that it will be difficult for any country to use them without international condemnation," he said. mission to the United Nations, said: "We are opposed to any ban on cluster munitions. We do canada goose jackets not believe they are indiscriminate weapons."

Melkert said there are billions of unused cluster munitions stockpiled by some 75 countries. Most of canada goose outlet store those countries are now backing a treaty banning such weapons. allies such as Britain, Denmark, France, Germany, Japan, the Netherlands and Sweden are lobbying for the exclusion of some cluster bombs from the ban, diplomats canada goose jackets canada said.

Some also are pushing for a transition period during which the devices could still be used and for deletion of a clause in the draft treaty approved in New Zealand this year that bars signatories from engaging in joint operations with countries actively using cluster munitions.

"As it stands, the draft treaty is a strong, comprehensive ban on cluster munitions. Any attempts to water it down should be rejected completely," Goose said. Thomson Reuters journalists are subject to an Editorial Handbook which requires fair presentation and disclosure of relevant interests.

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As Marx noted, labor=value. And the capitalists working with financial entities know their money is nothing but worthless paper unless it can harness the labor of billions and "grow". Finance Minister Thierry Breton and the heads of the two companies were holding talks with trade unions on Monday morning to try to break down their opposition. The unions are rightfully fearful of any merger, even one designed to "save" the energy company beats cyber monday from foreign control. This is because all mergers=people losing jobs. Since mergers involve exchanges of money, this has to be paid for and the only method is via labor concessions. Plans for the alliance have angered Italy and could alarm the European Commission because of concerns that France's stated policy of economic patriotism'' goes against the spirit of free movement of capital. Yet they are understandably nervous of losing all control of their own country yet they will happily buy similar things in the USA or neighbors like Belgium, in Europe. These vacillations are typical of all "free traders" who want freedom to invade other people's systems but want to do it from a fortress of solitude.

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Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice

n 2, 166 37 canada goose black friday Prague, Czech Republic23rd Medical Faculty, Charles University, Rusk 87, 100 00 Prague 10, Czech Republic3Department of Parasitology, Faculty of Science, Charles University, Vini 7, 128 44 Prague, Czech Republic4Department of Genetics and Microbiology, Faculty of Science, Charles University, Vini 7, 128 44 Prague, Czech Republic5Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The NetherlandsCorrespondence: Marie Lipoldov Institute of Molecular Genetics, Fleming. n 2, 166 37 Prague, Czech Republic.

Received 20 September 2001; Revised 20 November 2001; Accepted 26 November 2001.

Top of pageAbstractThe strain BALB (BALB is a high producer, and STS (STS) a low producer of IgE after Leishmania major infection. Strains CcS 16 and 20 exhibit a high and a low IgE level, respectively. In their F2 hybrids with BALB we mapped nine Leishmania major response (Lmr) loci. Two of them we previously found to influence IgE level in CcS 5. IgE production in CcS 16 is controlled by loci on chromosomes 2, 10, 16 and 18 and in CcS 20 by loci on chromosomes 1, 3, 4, 5 and 8. The STS alleles of loci on chromosomes 1, 4, 5, 8 and 10 were associated with a low, whereas the STS alleles on chromosomes 16 and 18 with a high IgE production. The loci on chromosomes 2 and 3 have no apparent individual effect, but interact with the loci on chromosomes 10 and 1, respectively. The loci on chromosomes 10 and 18 were mapped in the regions homologous with the human regions containing genes that control total serum IgE and intensity of infection by Schistosoma mansoni, suggesting that some Lmr loci may participate in the pathways influencing atopic reactions and responses to several parasites. The definition of genes controlling anti parasite responses will permit a better understanding of pathways and genetic diversity underlying the disease phenotypes.

Keywords: IgE; quantitative trait; Leishmania major; mouse model; gene interaction

Top of pageIntroductionImmunoglobulin E (IgE) canada goose jackets and its receptors are believed to have evolved as a mechanism to protect mammals against parasites, namely the helminth infections.1 However, some apparently innocuous antigens can subvert this system to provoke an allergic response.2

IgE response is controlled by a complex network of molecular interactions that includes IgE, low and high affinity receptors for IgE (Fc and Fc respectively), integrins CD11b proteins ( complement receptor CR2, cytokines and hormones.2,3

At least two signals are necessary for the induction of IgE production: either interleukin (IL) 4 or IL 13 and CD40 pairing. A pathway independent of CD40L which is mediated via CD30L and requires IL 4 and IL 5 to induce IgE production was also described.4 IL 5, IL 6, IL 9 and TNF augment IgE expression, whereas interferon (IFN) IFN IL 8, IL 10, IL 12 and PGE2 inhibit this process (reviewed in Romagnani5). IgE receptors Fc and Fc (CD23) influence IgE level by a feedback mechanism.2 Obviously, the observed IgE level would be the result of interrelationship of all these multiple known factors and perhaps some unknown factors as well.

Several loci determining genetic control of IgE level in humans have been described,6 but there are considerable differences between results obtained in different studies.7 One of the reasons for these discrepancies may be the definition of phenotype, but there are other factors that make analysis of multigenically regulated diseases in humans difficult, and which include genetic heterogeneity of human populations, gene interactions, high frequency and incomplete penentrance of disease causing alleles and a great complexity of environmental factors. These limitations are especially important in the cases where there are large numbers of segregating disease loci. As different genotypes can conceivably lead to the same phenotype, the same disease in different families could be controlled by different genes.8 Some of these problems could be overcome by the use of a mouse model.

As a model for study of complex genetic regulation of IgE production we used the response to infection of Leishmania major in mouse. L. major is a protozoan parasite that infects mononuclear phagocytes of vertebrate host. In most mouse strains this infection causes no or only transient pathological changes, whereas some strains develop systemic visceral disease with skin lesions, splenomegaly, hepatomegaly, anemia, cytokine imbalance and increased serum IgE.9 The susceptible strain BALB (BALB exhibits a high, whereas the resistant strain STS (STS) a low serum IgE level after L. This series comprises 20 homozygous strains all derived from two parental inbred strains: the strain BALB and the strain STS. In our previous studies we have selected the most resistant RC strain CcS 512 and identified two loci that control IgE after L. major infection, Leishmania major response 3 (Lmr3) and Lmr5 on chromosomes 5 and 10, respectively.10 Interestingly, Lmr5 maps to the segment of mouse chromosome 10, homologous with human region 12q15 q24.1, which controls total IgE concentrations in humans.13 In the present study we have analyzed the control of IgE production in low and high producing strains CcS 20 and canada goose 16, respectively.

Top of pageResultsStrain differences in serum IgE levels in recombinant congenic strainsWe measured levels of total serum IgE after 8 weeks of L. major infection in 305 female mice of BALB STS and 20 CcS RC strains. The results are given in Figure 1. Non infected canada goose black friday CcS strains exhibited lower mean IgE production than BALB but the differences were not significant. Eleven RC strains CcS 1, 2, 5, 6, 7, 9, 10, 13, 15, 17, 20 exhibited lower IgE levels than the background strain BALB after L. major infection, the lowest IgE levels being observed in the strain CcS 5 (P 2.87 10 The low producers CcS 5 and 20 and a high producer CcS 16 were selected for further investigation. Genetic analysis of IgE production in CcS 5 was described elsewhere,10 control of IgE production in CcS 16 and 20 has been analyzed in this study. major infected mice of the parental strains BALB STS and the CcS strains. Means and standard errors were computed by analysis of variance. IgE levels in serum in ng were transformed to the power of 0.5 in order to obtain normal distribution. Values significantly lower than BALB are marked by asterisks. At least 10 females from each strain were tested. (The absolute values reported here differ from the values reported by Lipoldov et al, 200010 due to an error in measurement in the previous paper.)

Full figure and legend (32K)

Genetic control of IgE production in F2 hybrids between BALB and CcS 16Statistical evaluation of linkage of the IgE production in 578 F2 hybrids between BALB and CcS 16 is given in Table 1. A linkage was detected to the marker D10Mit103 on chromosome 10 (corr. P 0.00000239), in the region containing the Lmr5 locus, previously shown to control IgE level in CcS 510 (Figure 2). The linkage analysis also revealed three novel loci controlling IgE level: Lmr12 on chromosome 16 linked to the marker D16Mit126 (corr. P 0.00529), Lmr13 on chromosome 18 near the marker D18Mit35 (corr. P 0.00659) and Lmr14 on chromosome 2 near the marker D2Mit389. Lmr14 shows no individual effect, but it influences IgE level in interaction with Lmr5 on chromosome 10 (corr. P 0.0160). BALB allele of Lmr5 determines high IgE level, whereas BALB alleles of Lmr12 and Lmr13 determine low IgE production. Combination of BALB homozygotes in Lmr5 and STS homozygotes in Lmr14 or combination of BALB homozygotes in these loci result in increased IgE levels. No effect of age or experiment on any linkage was observed. The regions of STS origin are represented as dark, the regions of undetermined origin are shaded. Only the BALB markers at the position between BALB and STS segment and STS markers that were used for typing are shown. The markers that exhibit significant P values (corrected P 0.05) are in boxes. C and S indicate the presence of BALB and STS allele, respectively. NS, not significant, is used for P 0.05. 0.05 Unfortunately we are unable to provide accessible alternative text for this. Statistical evaluation revealed five loci that control IgE level in CcS 20 (Table 2a,b). One of them maps to the markers D5Mit55, D5Mit114, D5Mit175 on chromosome 5 (corr. P 0.00000243, 0.00178 and 0.0477, respectively). Previously we found that this region contains the locus Lmr3 that controls the IgE level in CcS 510 (Figure 2). We also detected four additional novel loci: Lmr8 near to the markers canada goose outlet toronto D1Mit14, D1Mit227 and D1Mit17 on chromosome 1 (corr. P 0.0000557, 0.00157 and 0.0209, respectively), Lmr9 near the marker D4Mit149 on chromosome 4 (corr. P 0.00313), and to Lmr10 near the markers D8Mit125 and D8Mit54 (corr. P 0.000731 and 0.0000111, respectively). Lmr11 is marked by D3Mit11 and D3Mit25 and it does not influence the IgE level independently but interacts with Lmr8 on chromosome 1 (corr. P 0.0229 and 0.00522, respectively). BALB alleles of Lmr8, 9 and 10 are associated with high IgE levels, whereas STS alleles of these loci determine low IgE levels (Table 2a). BALB alleles of Lmr8 (D1Mit14) and Lmr11 (D3Mit11 and D3Mit25) interact in determining IgE levels, lower levels being observed in interaction of BALB and STS homozygotes in Lmr11 and Lmr8, respectively (Table 2b). Influence of the experimental group was apparent (P 0.0001 but no significant interaction between experimental group and linkage was observed. No effect of age was found on any linkage.

Table 2 (a) Linkage of the IgE production in F2 hybrids between CcS 20 and BALB In order to normalize the distribution of the observed IgE levels required for ANOVA, 1 was added to the decadic logarithm of the measured values and the values were transformed to the power of 0.3. of the transformed values computed by ANOVA. C and S indicate the presence of BALB and STS allele, respectively. NS, not significant, is used for P 0.05. (b) Interactions between loci (P 0.000571, Corr. P 0.0229). 0.05. (b) Interactions between loci (P Full table (43K)

Top of pageDiscussionWe have studied the strain difference in L. major induced serum IgE levels between BALB and STS using the 20 RC strains of CcS series. If the difference in IgE expression between BALB and STS was controlled by an additive effect of a very large number of non linked loci, each CcS strain would likely receive at least some of them from the donor strain, and hence most of all CcS strains would exhibit a similar, intermediate response. However the large differences between individual CcS strains and the number of high and low responder strains (Figure 1) suggest that a relatively limited number of genes is involved in the control of IgE level in serum. This was indeed the case when three CcS strains, CcS 5, 16 and 20 were selected and genetically analyzed. In our previous studies we have identified two loci that control IgE level in the strain CcS 5, Lmr3 and Lmr5 on chromosomes 5 and 10, respectively.10 In the present paper we describe seven additional loci that control IgE level in the strains CcS 16 and 20. The information about all nine loci is summarized in Table 3. The region on chromosome 10 overlaps with the locus Lmr5 that we have mapped in the cross between BALB and CcS 5. It is therefore possible that two linked loci on chromosome 10 control the IgE levels in infected mice: Lmr5 in the vicinity of Ifng and a more telomerically located gene. This part of mouse chromosome 10 is homologous with the long arm of human chromosome 12, which was reported to control total serum IgE.13 Lmr12 marked by D16Mit126 is localized in the central region of chromosome 16 with the maximal length 6 cM and contains no obvious candidate genes. We have mapped to this segment the locus Cypr1 (Cytokine production 1) that controls IL 4 production.16 IL 4 is a strong inducer of IgE.5,14 CcS 16 carries on chromosome 18 an STS derived segment with the maximal length 30 cM. Lmr13 maps to the central part of this segment, in the proximity of genes csf1r (colony stimulating factor 1 receptor), Cd14 (CD14 antigen) and Adrb2 (adrenergic receptor, beta 2) that were shown to influence IgE level. CSF or stimulation of adrenergic receptor led to increase of IgE level,17,18 whereas CD14 engagement inhibits the IgE synthesis.19 Lmr13 is situated in the part of mouse chromosome 18 that is homologous with the human segment 5q31 q33 known to be involved in the control of atopy and defense against pathogens. Both polymorphism in the 5 flanking region of the human CD14 on chromosome 5q31.1 and in adrenergic receptor were shown to be associated with total serum IgE.20,21 Locus SM1 in the region 5q31 q33 determines the intensity of infection by Schistosoma mansoni22 and may also influence blood level of Plasmodium falciparum.23 IgE plays an important role in the response to helminth infections1 and therefore it cannot be excluded that responses controlled by Lmr13 and SM1 are influenced by the same (homologous) gene. Lmr14 is localized on central part of chromosome 2 that contains no obvious candidate genes.

IgE production in CcS 20 is controlled by five loci on chromosomes 1, 3, 4, 5 and 8 (Tables 2a, b and 3, Figure 2). The locus on chromosome 5 overlaps with Lmr3 that controls IgE production in CcS 5. CcS 20 carries on chromosome 5 three STS derived segments. Lmr3 maps to the centromeric region with the maximal length 33 cM. No obvious candidate genes are localized in this region. We have mapped to this segment the locus Cypr3 that controls IL 10 production.16 IL 10 was described to inhibit IL 4 induced IgE synthesis.24 Interestingly, Tir2 (Try panosoma infection response 2) also maps to this region.25 Lmr8 maps to the two STS derived segments on the distal part of chromosome 1, with the maximal length 8.2 and 7.1 cM, respectively. We have also mapped to this segment the locus Cypr2, which controls mitogen induced IL 10 production.16 Lmr9 maps to the centromeric part of chromosome 4, with the maximal length 1.9 cM, where there is no obvious candidate gene. Lmr10 maps to the proximal and central part of chromosome 8 with the maximal length 16 cM. In this region Scvr (scavenger receptor) and Casp3 (caspase 3) are found that are involved in apoptotic reactions induced by intracellular pathogens.26 Lmr11 is localized on the central part of chromosome 3 with the maximal length 41.2 cM. Lmr3 determines splenomegaly, hepatomegaly and IFN level in serum, whereas Lmr5 controls lesion size, splenomegaly and levels of IL 2 and IFN in serum.10 Similar phenomena have also been observed in CcS 16 and CcS 20. All IgE controlling loci, except Lmr9 and Lmr12, influence development of cutaneous and visceral leishmaniasis (Vladimirov et al, submitted). The question whether this reflects a causative relationship and whether these parameters are controlled by a single gene or by a complex of two or more linked genes needs to be solved by recombinant mapping.

We have analyzed three RC strains that cover approximately 35 of differences between BALB and STS. These differences are controlled by nine genetic loci. Despite the overall genetic similarity between the strains CcS 5, 16 and 20 (each has 87.5 of the BALB genome), only two loci control IgE level in more than one strain. This finding resembles the situation observed in studies of human atopy where linkage observed in one population is not seen in the other population, sometimes from the same country.7 RC strains might therefore serve as a model of these different human families. Their analysis could help both to identify IgE controlling genes and to elucidate interactions between different alleles in diseases caused by disregulation of IgE production.

Top of pageMaterials and methodsMiceFemales of strains BALB STS and RCS of CcS series 8 to 26 weeks old at the time of infection, were from the breeding colony of P. Demant. When used for these experiments, the RCS were in the generation 28 of inbreeding and therefore highly homozygous. The parts of RCS genomes inherited from the BALB or STS parents were defined.31 Female F2 hybrids between CcS 16 and BALB (age 14 to 17 weeks at the time of infection) and CcS 20 and BALB (age 9 to 14 weeks) were produced at the Institute of Molecular Genetics. Each cross was tested in four independent experimental groups.

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Building a solid state tesla coil

Thanks for posting this spark light. My first tesla coil. It was definitely a learning experience, and ugg boots on sale 70% off exciting to get that first spark. A note to anyone trying this; if you have a problem along the way read the comments, google and search youtube. A few of my questions were answered that way. I started this project back in November 2013. I have since altered a few things like making a home built torroid for the top (instead of an oil filter wrench in the first photo) and figuring out how to make it play music. I plan on making an instructable as well sometime soon.

They determine the on and off time of the interrupter. If you have an oscilloscope you can build the interrupter circuit and see how they affect the waveform. Just set them somewhere in the middle. Doesn't really matter it will work no matter how they are set. If you get your coil running you can adjust them while its on and you will see and definitely hear the adjustments you make. When I first made this coil I actually used a circuit from the 555 data sheet to make a 50% duty cycle timer as the interrupter.

Now, the coil won't produce spark. I use a step down transformer to step the voltage down to 110 (220 110), and I also put a variable SSR (solid state resistor) to make a cheap ugg boots on sale 70% off variac. The major problem tho, is that the MOSFETS are quickly overheating and shutting down, making the transformer buzz. The odd part is that the MOSFETS are starting to heat up at only 30v. The coil at this point is barely making a park.

The coil setup is 4T primary, and secondary 0.35 mm x 1000t on a 75mm acrylic tube.

Any help would be greatly appreciate!

I was wondering if it were possible to change some of the specs of the resonator while still making the TC operate as you designed it. I wanted to use a secondary and toroid that I built for a different project. My thinking is that if I could keep 3 of the following specs the same, the device would still work with similar results. I fixed the resonant frequency (calculated from the secondary and toroid specs); the turns ratio; and the primary inductance to be equivalent with your design. So am I forgetting another spec or could I build a workable TC by controlling these features to be the same as yours?

If your interested:Turns Ratio: 6.25:1300Argh. I work in a physics lab at a university and I'm having trouble getting this thing to work. The low voltage side seems to work fine. I hooked the antenna to a 200kHz sine source and I'm getting a nice digital output broken by the 555's input.

The high voltage side behaves really strangely. When I measure the voltage across the Primary output, I get 8 volts. So theoretically my circuit is doing the right thing. When I connect one end of the primary output to mains ground, I can hear the current flowing at the 555's interrupt frequency. On a related note, it's a good thing I put fuses in this thing. Is the idea that the 200kHz feedback from the secondary will make it through this decaying effect? Any suggestions?

As far as I can tell it was working fine the whole time, but the primary coil wasn't positioned right. With a SGTC at least you can see/hear that it SHOULD be working, but this one was silent until sparks started flying. A 5 6 turn primary is dead on for a simple loop of wire, but I need to do some experimenting with diameters and shapes to get maximum spark length. Also, I was semi surprised to discover that the direction of the primary loop matters! As in, if I get the coil working then switch the ends of the primary around but keep the same number of loops/position/etc, it isn't nearly as good. So for those of you with a build that isn't smoking and sizzling but also isn't doing anything, mess with the primary coil. A lot. That's probably it. Also a big antenna helps, aluminum foil works great.

Do not use a dimmer. It does not work the same as a variac. (It'd probably catch fire) If at all possible, use caps rated for double the input voltage, as this will key you much more safe from fires. If you need to find a supplier, you could use digiKey, they have always been awesome for me.

120 volts in the place of each 0.68uF.

If you're absolutely sure about your soldering and are able to verify somehow that the circuit works, go ahead and and just hook it up. The variac is just a large safety buffer, and as long as you have some kind of circuit breaker, you should be fine. Best of luck!

While there are oscilloscope programs out there, unless you use an actual oscilloscope device that plugs in to your computer, this project would kill it. I'm not sure if sound cards even have an adequate sample rate, but my best recommendation is to not do anything ugg boots uk outlet like that until you have at least a usb oscilloscope, because without isolation, you will damage your computer. It is possible to find decently priced usb oscilloscopes around. I hope to have the time soon to post an intractable info page all about oscilloscopes. Best of luck finding a solution.

You can't really use prf audio modulation on this coil. You would have to completely redesign the drive circuit using some kind of phase locked loop and DAC. I would go with using PWM to audio modulate this. For one thing, PWM is MUCH more efficient with this design. PRF would not work even if you had a pll design, because the way this coil keeps kicking itself into oscillation is by interrupted drive. every time you enable the gate drive chips, it sends a short pulse to the primary. For PRF modulation to work, you would need continuos drive, a mode that unfortunately, is not supported with standard feedback coils reliably. I would not recommend using a micro controller unless it has high clock speeds, as it does take some time to read an analog output, and you will want a high frequency pwm signal do as to preserve a high sample rate. If you wanted to use PWM, A better way to do this is to use an oscillator that supports PWM ilk the tl494 (I think) Because it can oscillate at high frequencies and is very reliable. The key thing about tesla coils is there voltage and frequency. If you have anything giving input, make sure it is isolated, or at least use something that you won't mind if it gets damaged. Stay safe, and make some beats!

Trust me, this is no easy thing to understand. How PWM makes a tesla coil produce sound is my varying the amount of power that is going through to coil .(And thus the streamers) Because there are more intense arcs when there is a larger amount of power (so to speak) You can vary how hot the air is in it's ionization path. Because the arc makes the air hot, you are able to control the density, and because there is no air added or removed, it occupies a larger or smaller volume according to how much power you want to put through it. So, if you vary the pulse width, you are varying the level that the wave is at. To produce sound, you then raise and lower the duty cycle at the frequency of the sound you want to make. However, if you want ugg boots sale free shipping to produce sound like that video, it is a lot simpler. That video is producing square wave output, so all you have to do is turn the whole coil on and off at the frequency of the sound you want to produce. (So, if you wanted to make the note for middle C, you would turn the coil on and off at 440Hz, or have 1/220th of a second of it being on and being off, repeated for as long as you would want the note to play.)

Generally, you want to have a pwm frequency at about 30 80 khz. It is hard to overload this uggs clearance coil, as the primary coil while in oscillation acts as a heavy inductive load. It "absorbs" most of the power and transfers it to the secondary.

As for the shielding, these ic's are very simple, as well as the fact that the coil actually doesn't output as much emf as one might think. I have yet to set up a proper field density test, but at about 1 foot away from the coil, the voltage seen on the probe is + 2 volts. As well, the chips are mostly simple logic and analog devices. Analog is much more robust. (assuming proper decoupling.)

First off: great instructions spark light I have been searching the interwebz for a few days now and found many different instructions, including Steve Ward's, and believe yours are the most comprehensive and easiest to follow kudos!

This is what I am hoping to do too, that is produce audio square waves at a variety of frequencies, and my question is: what is the operational input frequency range for this circuit?

I understand the bit about replacing the interrupter with a PWM circuit, but you say that the interrupter runs around 20 200Hz, and then state that if you use PWM it should be 30 80kHz, so I would gather that you can easily input the audio range of 20 20kHz successfully, but wanted to see if you had more info before buying these exact parts. Looks like you said a 50% duty cycle would be good. I would assume you start to hear volume fall off with constant power at the lower frequencies though so I may try to compensate a little with the duty cycle.

Either way, thanks for the awesome contribution to this world Tesla would be proud!

The interrupter oscillates at around 20 200 Hz if i remember correctly (which is very variable due to on/off time controls being separate.)

The reason you don't want to have a very high to full duty cycle is because in order for this thing to start oscillation, it needs the slight kick that happens when the interrupter is enabled. This prevents it from going into a grey area on the mosfets.

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LONDON, Ont. When Canadian chefs participate in international culinary competitions, they often feature wild game maybe elk, bison, caribou or moose foods that aren't staples in most homes here but are recognized worldwide as Canadian delicacies.

His latest cookbook, published by Company's Coming Publishing Ltd., covers all the wild game mentioned, plus venison (white tailed deer), pronghorn, wild boar, bear, rabbit, beaver, muskrat, waterfowl (Canada goose and duck), upland fowl (grouse, pheasant, woodcock, wild turkey and quail) and frog. He has hunted most of them and has enjoyed dining on all of them. The book also includes suggestions and recipes for side dishes, marinades, sauces and desserts.

Morrison grew up eating wild game in the Laurentians of Quebec and developed an appreciation for cooking and experimenting with wild game recipes at his uncle's restaurant, Alfred's Beefeater Steakhouse, near Mont Tremblant.

But he recognizes most people don't hunt or trap food for supper and though all the meats featured in his book are classified as "wild" game, in fact all are raised commercially across Canada. In most provinces, these farmed meats are the only kind shoppers will find being sold in supermarkets, specialty shops and by online vendors.

"Nova Scotia and Newfoundland are the only two provinces where hunted wild game can actually make it to a restaurant or supermarket," Morrison says. "It's illegal in the rest of Canada. So the game meat you find in the other provinces is farm raised."

However, Quebec has started a pilot project allowing 10 restaurants in Montreal to serve hunted wild game and the hope, says Morrison, is that once officials are assured it is properly regulated, hunted wild game may be approved for menus in other parts of the province.

"Whether it's hunted or farm raised, it's still essentially the same product," he says. "It's just a matter of how the product is acquired."

Even the farmed game animals "are not raised in these pens. They're raised more in a natural setting, to represent their natural environment, so there's no real difference." But the harvesting, aging and processing are all done to government standards, a reassurance for consumers who may be wary of the "wild" part or concerned about conservation.

Despite this, some people "just can't seem to get past the stigma of game meats," Morrison admits, also conceding there is a certain gamey quality to the meat, what he prefers to call a "more full bodied flavour, with a slightly more pungent odour." It is stronger in some than others, with venison probably the strongest and waterfowl somewhat stronger than land fowl, but not that different than farmed counterparts.

Moose and elk, on the other hand, are quite mild, he says, and muskrat and beaver "are both canada goose outlet delicious." Beaver, he says, is reminiscent of lamb.

The unique flavour and texture are two things about wild game that appeal to Morrison, who has degrees in both environmental management and fish and wildlife biology. But the biggest advantage of game meat is that "it's more organic, low in fat and low in cholesterol."

These health benefits also mean it is a little more difficult to cook.

The key is "low and slow," canada goose jackets canada Morrison says low cooking temperature and a slow cooking period to prevent the canada goose boxing day meat from getting dry. It also is important to use marinades, frequent basting or bacon wrapping to keep the meat as moist as possible.

Steaks and roasts would be "typically served medium to medium rare . keeping a bit of pinkness in the centre."

With wild boar, like other kinds of pork, "you have to be a little more vigilant, keeping in mind that you still don't want to overcook."

Most experts agree cooking pork to 70 C (160 F) or medium is safe and will keep it juicy and tender. Ground pork and sausages should be cooked to well done.

Morrison's book contains several slow cooker and stew recipes, another way to ensure the meat will stay moist and tender.

"I am a huge fan of stews (and) I believe that wild game stew, regardless of the game meat featured in it, is a traditionally Canadian dish."

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